秋水仙碱的副作用

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Colchicine is an alkaloid derived from crocuses that has anti-inflammatory properties. It is used as a treatment for gouty arthritis which results from a building up of uric acid in the joints. Because it is not a uricosuric, which increases the output of uric acid in urine, it is often combined with uricosurics to encourage the expelling of the uric acid from the joints.
秋水仙碱是一种来自番红花的生物碱,具有抗炎特性。它被用于治疗痛风性关节炎,痛风性关节炎是由于关节中尿酸积累而引起的。由于它并不是促进尿酸从尿液中排出,因此秋水仙碱通常与促尿酸从尿液中排出的药物结合使用,以促进尿酸从关节排出。

Off label, it is used for other types of arthritis, leukaemia, multiple sclerosis and cirrhosis. It is absorbed from the intestinal tract and metabolised in the liver before being excreted in faeces.
在其它临床应用领域,秋水仙碱还可用于其他类型的关节炎,白血病,多发性硬化和肝硬化。秋水仙碱从肠道吸收并在肝脏中代谢,经粪便排泄到体外。

It is contraindicated for patients with blood abnormalities and severe gastrointestinal, renal, hepatic or cardiac disease. Skin irritation may occur from intramuscular or subcutaneous injection. Common side effects include nausea, vomiting, diarrhoea and abdominal pain. Possibly life-threatening side effects are bone marrow depression, a severe drop in the number of white blood cells in the body (agranulocytosis) and aplastic anaemia.
秋水仙碱的禁忌症包括:血液异常和严重胃肠道,肾脏,肝脏或心脏疾病患者。肌肉注射或皮下注射可能会引起皮肤刺激。常见的副作用包括恶心,呕吐,腹泻和腹痛。可能危及生命的副作用是骨髓抑制,体内白细胞数量急剧下降(粒细胞缺乏症)和再生障碍性贫血。

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